HYDROGEN PEROXIDE VAPOUR (HPV) GENERATOR
Applications
  • GMP cleanrooms
  • Aseptic processing
  • Biologics
  • Biomedical
  • Biosafety/security
Description
  • Large scale room/zone bio-decontamination
  • Parametric cycle control
  • Simple to operate “plug and play” system
  • Excellent material compatibility including sensitive electronics
  • Dual circuit technology for optimum cycle times
  • Gas distribution catalytic aerator included
  • Siemens® colour touch screen
  • GAMP compliant software
  • Compact and highly portable design
  • Easily cleanable external surface
  • Volt-free contacts for external signals
  • Integral thermal paper printer
  • Remote start/stop
  • Unique Bioquell parametric control process no need for gas cycle development
  • Cycle edit and store facility for new applications
  • Effective against a wide range of micro-organisms
  • Hydrogen peroxide vapour gas sensor

Safe and simple to operate:
  • The control lectern is removed from the Bioquell Z-2 at an appropriate control point; the Bioquell Z-2 is then placed inside the contaminated zone
  • With the lectern in place outside the area to be decontaminated, the area is sealed with tape and any ventilation systems are isolated
  • Room dimensions are entered allowing the Bioquell Z-2 to calculate HPV cycle parameters. Final safety checks are made via the control panel on the lectern. The cycle can then be activated
  • Multi-directional nozzles deliver the vapour, switching to automatic aeration (via parametric control) after the gassing phase is complete
  • The touch screen displays the cycle progress and indicates when the cycle is complete
  • At the end of the cycle, HPV levels are manually checked from outside the room and the area is then rapidly put back into service
Schematic of Bioquell HPV concentration/time graph
  1. HPV introduced – initial rapid increase in HPV concentration
  2. HPV saturation/“dew point” achieved – onset of rapid bio-decontamination
  3. HPV gassing plateau – sustained micro-condensation effecting bio-deactivation
  4. Dwell period (contact time)
  5. Aeration – removal of HPV from the atmosphere typically by catalytic conversion to water vapour and oxygen, leaving no residues

Schematic of dew point and Bioquell kill dynamics
  1. Injection of HPV into the enclosure starts (t=0)
  2. Only slight decline in biological indicator population prior to dew point
  3. Rapid micro-biological kill occurs immediately after saturation/“dew point” is achieved – process optimised to achieve reliable 6-log sporicidal reduction on all exposed surfaces
  4. Onset of micro-condensation correlates with rapid bio-deactivation
  5. Bio-deactivation achieved via micro-condensation (invisible layer) of hydrogen peroxide (2-6μm)